IMMUNOBIOLOGY HIV-1 matrix protein p17 binds to the IL-8 receptor CXCR1 and shows IL-8–like chemokine activity on monocytes through Rho/ROCK activation

نویسندگان

  • Cinzia Giagulli
  • Anna K. Magiera
  • Antonella Bugatti
  • Francesca Caccuri
  • Stefania Marsico
  • Marco Rusnati
  • William Vermi
  • Simona Fiorentini
  • Arnaldo Caruso
چکیده

1Section of Microbiology, Department of Experimental and Applied Medicine, and 2Section of General Pathology, Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Brescia, Italy; 3Department of Pharmaco-Biology, University of Calabria, Arcavacata di Rende (Cosenza), Italy; and 4 Department of Pathology, School of Medicine, University of Brescia, Brescia, Italy

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HIV-1 matrix protein p17 binds to the IL-8 receptor CXCR1 and shows IL-8-like chemokine activity on monocytes through Rho/ROCK activation.

Exogenous HIV-1 matrix protein p17 was found to deregulate biologic activities of many different immune cells that are directly or indirectly involved in AIDS pathogenesis after binding to unknown cellular receptor(s). In particular, p17 was found to induce a functional program in monocytes related to activation and inflammation. In the present study, we demonstrate that CXCR1 is the receptor m...

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تاریخ انتشار 2012